DTX1 antibody
Product Specifications
Background
Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity(By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB(Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1.
Synonyms
E3 ubiquitin-protein ligase DTX1|Protein deltex-1 (Deltex1, hDTX1)|RING-type E3 ubiquitin transferase DTX1|DTX1
Gene ID
1840
UniProt
Q86Y01
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
deltex homolog 1(Drosophila)
Target
DTX1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IF, IHC
Field of Research
Signal Transduction, Metabolism, Cardiovascular, Immunology, Developmental biology
Purification
Immunogen affinity purified
Dilution
IHC: 1:20-1:200; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
67-72, 58-63 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
Curated Selection
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