DIS3L2 antibody
Product Specifications
Background
3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem(ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation.
Synonyms
DIS3-like exonuclease 2 (hDIS3L2)|DIS3L2|FAM6A
Gene ID
129563
UniProt
Q8IYB7
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
DIS3 mitotic control homolog-like 2
Target
DIS3L2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
65 kDa/99 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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