DACH1 antibody
Product Specifications
Background
Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity) . Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity) .
Synonyms
Dachshund homolog 1 (Dach1) |DACH1|DACH
Gene ID
1602
UniProt
Q9UI36
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Dachshund homolog 1 (Drosophila)
Target
DACH1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC, IP, WB
Field of Research
Neuroscience, Stem Cells, Metabolism, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
97-100 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC, IP, WB
Immunogen Sequence
176-521 aa
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