CYP4F3 antibody
Product Specifications
Background
Isoform CYP4F3A: Catalyzes the omega-hydroxylation of leukotriene-B (4), a potent chemoattractant for polymorphonuclear leukocytes, it has low activity for arachidonic acid. Isoform CYP4F3B: Shows arachidonic acid omega-hydroxylase activity by mediating conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE) (PubMed:11461919, PubMed:16820285) . Has a 30-fold higher Km for leukotriene-B (4) compared with CYP4F3A (PubMed:11461919) . Also converts eicosapentaenoate (EPA) to 20-hydroxyeicosapentaenoate (20-OH-EPA) (PubMed:16820285) . Acts as a polyunsaturated omega-3 fatty acids hydroxylase: mediates conversion of docosahexaenoate (DHA) to 22-hydroxydocosahexaenoate (PubMed:16820285) .
Synonyms
Cytochrome P450 4F3|20-hydroxyeicosatetraenoic acid synthase (20-HETE synthase) |CYPIVF3|Cytochrome P450-LTB-omega|Docosahexaenoic acid omega-hydroxylase CYP4F3|Leukotriene-B (4) 20-monooxygenase 2|Leukotriene-B (4) omega-hydroxylase 2|CYP4F3|LTB4H
Gene ID
4051
UniProt
Q08477
Host
Rabbit
Reactivity
Human
Immunogen
Cytochrome P450, family 4, subfamily F, polypeptide 3
Target
CYP4F3
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
60 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB
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