CYP4F3 antibody
Product Specifications
Background
Isoform CYP4F3A: Catalyzes the omega-hydroxylation of leukotriene-B(4), a potent chemoattractant for polymorphonuclear leukocytes, it has low activity for arachidonic acid.
Isoform CYP4F3B: Shows arachidonic acid omega-hydroxylase activity by mediating conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid(20-HETE)(PubMed:11461919, PubMed:16820285). Has a 30-fold higher Km for leukotriene-B(4) compared with CYP4F3A(PubMed:11461919). Also converts eicosapentaenoate(EPA) to 20-hydroxyeicosapentaenoate(20-OH-EPA)(PubMed:16820285). Acts as a polyunsaturated omega-3 fatty acids hydroxylase: mediates conversion of docosahexaenoate(DHA) to 22-hydroxydocosahexaenoate(PubMed:16820285).
Synonyms
Cytochrome P450 4F3|20-hydroxyeicosatetraenoic acid synthase (20-HETE synthase)|CYPIVF3|Cytochrome P450-LTB-omega|Docosahexaenoic acid omega-hydroxylase CYP4F3|Leukotriene-B(4) 20-monooxygenase 2|Leukotriene-B(4) omega-hydroxylase 2|CYP4F3|LTB4H
Gene ID
4051
UniProt
Q08477
Host
Rabbit
Reactivity
Human
Immunogen
cytochrome P450, family 4, subfamily F, polypeptide 3
Target
CYP4F3
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
60 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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