CXXC5 antibody
Product Specifications
Background
May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity) . Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788) . May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (PubMed:23303788) .
Synonyms
CXXC-type zinc finger protein 5 (CF5) |Putative MAPK-activating protein PM08|Putative NF-kappa-B-activating protein 102|Retinoid-inducible nuclear factor (RINF) |CXXC5
Gene ID
51523
UniProt
Q7LFL8
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
CXXC finger 5
Target
CXXC5
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
35-40 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB
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