CX3CL1 antibody
Product Specifications
Background
Acts as a ligand for both CX3CL1 and integrins. Binds to CX3CR1(PubMed:23125415, PubMed:9931005, PubMed:21829356). Binds to integrins ITGAV:ITGB3 and ITGA4:ITGB1. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site(site 1) in integrins. In the absence of CX3CR1, binds to a second site(site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1(PubMed:23125415, PubMed:24789099). The soluble form is chemotactic for T-cells and monocytes and not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium(PubMed:9024663, PubMed:9177350).
Synonyms
Fractalkine|C-X3-C motif chemokine 1|CX3C membrane-anchored chemokine|Neurotactin|Small-inducible cytokine D1|Processed fractalkine|CX3CL1|FKN|NTT|SCYD1
Gene ID
6376
UniProt
P78423
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
chemokine(C-X3-C motif) ligand 1
Target
CX3CL1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Stem Cells, Immunology, Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
90-100 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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