CUX1 antibody
Product Specifications
Background
Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions(MARs)(5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor(TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator(By similarity).
Synonyms
Homeobox protein cut-like 1|CCAAT displacement protein (CDP)|CDP/Cux p200|Homeobox protein cux-1|CDP/Cux p110|CUX1|CUTL1
Gene ID
1523
UniProt
P39880
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
cut-like homeobox 1
Target
CUX1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IF, IHC, IP
Field of Research
Neuroscience, Cardiovascular, Metabolism, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:1000-1:3000; IP:1:500-1:2000; IHC: 1:50-1:200; IF: 1:10-1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
80 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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