CTDSP1 antibody
Product Specifications
Background
Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.
Synonyms
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1|Nuclear LIM interactor-interacting factor 3 (NLI-IF, NLI-interacting factor 3) |Small C-terminal domain phosphatase 1 (SCP1, Small CTD phosphatase 1) |CTDSP1|NIF3|NLIIF|SCP1
Gene ID
58190
UniProt
Q9GZU7
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
Target
CTDSP1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
33 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB
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