CPNE1 antibody
Product Specifications
Background
Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes (PubMed:14674885) . Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner (PubMed:14674885) . Exhibits calcium-dependent phospholipid binding properties (PubMed:9430674, PubMed:19539605) . Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner (PubMed:23263657, PubMed:25450385) . May recruit target proteins to the cell membrane in a calcium-dependent manner (PubMed:12522145) . May function in membrane trafficking (PubMed:9430674) . Involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit (PubMed:18212740) . Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL (PubMed:18212740) .
Synonyms
Copine-1|Chromobindin 17|Copine I|CPNE1|CPN1
Gene ID
8904
UniProt
Q99829
Host
Rabbit
Reactivity
Human
Immunogen
Copine I
Target
CPNE1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA
Field of Research
Metabolism
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA
Curated Selection
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