COX6A1 antibody
Product Specifications
Background
Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in the electron transfer and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 1 (liver isoform) of subunit VIa, and polypeptide 1 is found in all non-muscle tissues. Polypeptide 2 (heart/muscle isoform) of subunit VIa is encoded by a different gene, and is present only in striated muscles. These two polypeptides share 66% amino acid sequence identity. It has been reported that there may be several pseudogenes on chromosomes 1, 6, 7q21, 7q31-32 and 12. However, only one pseudogene (COX6A1P) on chromosome 1p31.1 has been documented.
Synonyms
Cytochrome c oxidase subunit 6A1, mitochondrial|Cytochrome c oxidase polypeptide VIa-liver|Cytochrome c oxidase subunit VIA-liver (COX VIa-L) |COX6A1|COX6AL
Gene ID
1337
UniProt
P12074
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Cytochrome c oxidase subunit VIa polypeptide 1
Target
COX6A1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:200 - 1:2000; IHC: 1:20 - 1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
12 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC
Curated Selection
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