CNDP2 antibody
Product Specifications
Background
Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly (PubMed:19346245) . Acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway. An elevated level of CNDP2 activates the p38 and JNK MAPK pathways to induce cell apoptosis, and a lower level of CNDP2 activates the ERK MAPK pathway to promote cell proliferation (PubMed:24395568) . Isoform 2 may play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells (PubMed:17121880) . Catalyzes the production of N-lactoyl-amino acids from lactate and amino acids by reverse proteolysis (PubMed:25964343) .
Synonyms
Cytosolic non-specific dipeptidase|CNDP dipeptidase 2|Glutamate carboxypeptidase-like protein 1|Peptidase A|Threonyl dipeptidase|CNDP2|CN2|CPGL|HEL-S-13|PEPA
Gene ID
55748
UniProt
Q96KP4
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
CNDP dipeptidase 2 (metallopeptidase M20 family)
Target
CNDP2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IF
Field of Research
Cardiovascular, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
54 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IF
Curated Selection
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