CLSPN antibody
Product Specifications
Background
Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S-phase chromatin following formation of the pre-replication complex (pre-RC) . This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks.
Synonyms
Claspin (hClaspin) |CLSPN
Gene ID
63967
UniProt
Q9HAW4
Host
Rabbit
Reactivity
Human
Immunogen
Claspin homolog (Xenopus laevis)
Target
CLSPN
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IF, IP
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:1000; IP: 1:500-1:2000; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
240 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IF, IP
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