CLEC4M antibody
Product Specifications
Background
Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates.
(Microbial infection) Acts as an attachment receptor for ebola virus(PubMed:12050398, PubMed:12502850). Acts as an attachment receptor for hepatitis C virus(PubMed:15371595, PubMed:16816373). Acts as an attachment receptor for HIV-1(PubMed:21277928, PubMed:12502850). Acts as an attachment receptor for human coronavirus 229E(PubMed:17037540). Acts as an attachment receptor for human cytomegalovirus/HHV-5(PubMed:12433371). Acts as an attachment receptor for influenzavirus(PubMed:21191006). Acts as an attachment receptor for SARS coronavirus(PubMed:15479853). Acts as an attachment receptor for west-nile virus(PubMed:16415006). Acts as an attachment receptor for Japanese encephalitis virus(PubMed:24623090). Acts as an attachment receptor for Marburg virus glycoprotein(PubMed:15479853). Recognition of M.bovis by dendritic cells may occur partially via this molecule(PubMed:21203928).
Synonyms
C-type lectin domain family 4 member M|CD209 antigen-like protein 1|DC-SIGN-related protein (DC-SIGNR)|Dendritic cell-specific ICAM-3-grabbing non-integrin 2 (DC-SIGN2)|Liver/lymph node-specific ICAM-3-grabbing non-integrin (L-SIGN)|CLEC4M|CD209L|CD209L1|CD299
Gene ID
10332
UniProt
Q9H2X3
Host
Rabbit
Reactivity
Human
Immunogen
C-type lectin domain family 4, member M
Target
CLEC4M
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC, WB
Field of Research
Immunology, Cardiovascular, Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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