CLASP2 antibody
Product Specifications
Background
Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921) . Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN) . Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950) . This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514) . Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex.
Synonyms
CLIP-associating protein 2|Cytoplasmic linker-associated protein 2|Protein Orbit homolog 2 (hOrbit2) |CLASP2|KIAA0627
Gene ID
23122
UniProt
O75122
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Cytoplasmic linker associated protein 2
Target
CLASP2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Cell Division and Proliferation
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
140-160 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
244492-PE 100 µL
CDH11 (Cadherin 11, Type 2, OB-Cadherin (Osteoblast), CAD11, CDHOB, OB, OSF-4) (PE)
Ask
View Details 
138686 10 µg
Lin28B, Recombinant, Human, aa1-250, His-Tag (Protein Lin-28 Homolog B, CSDD2)
Ask
View Details 