CISD2 antibody
Product Specifications
Background
Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca (2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy.
Synonyms
CDGSH iron-sulfur domain-containing protein 2|Endoplasmic reticulum intermembrane small protein|MitoNEET-related 1 protein (Miner1) |Nutrient-deprivation autophagy factor-1 (NAF-1) |CISD2|CDGSH2|ERIS|ZCD2
Gene ID
493856
UniProt
Q8N5K1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
CDGSH iron sulfur domain 2
Target
CISD2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF, IP
Field of Research
Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
13-15 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF, IP
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