CHAF1A antibody
Product Specifications
Background
Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci(By similarity).
Synonyms
Chromatin assembly factor 1 subunit A (CAF-1 subunit A)|Chromatin assembly factor I p150 subunit (CAF-I 150 kDa subunit, CAF-I p150, hp150)|CHAF1A|CAF|CAF1P150
Gene ID
10036
UniProt
Q13111
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
chromatin assembly factor 1, subunit A(p150)
Target
CHAF1A
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC, WB, IP, IF
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:1000-1:4000; IP: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
150 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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