CD86 antibody
Product Specifications
Background
Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. (Microbial infection) Acts as a receptor for adenovirus subgroup B.
Synonyms
T-lymphocyte activation antigen CD86|Activation B7-2 antigen|B70|BU63|CTLA-4 counter-receptor B7.2|FUN-1|CD86|CD28LG2
Gene ID
942
UniProt
P42081
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
CD86 molecule
Target
CD86
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB,IHC,IF
Field of Research
Neuroscience, Immunology, Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:2000; IHC: 1:50-1:500; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
75 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF
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