CD59 antibody
Product Specifications
Background
Potent inhibitor of the complement membrane attack complex(MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.
The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes.
Synonyms
CD59 glycoprotein|1F5 antigen|20 kDa homologous restriction factor (HRF-20, HRF20)|MAC-inhibitory protein (MAC-IP)|MEM43 antigen|Membrane attack complex inhibition factor (MACIF)|Membrane inhibitor of reactive lysis (MIRL)|Protectin|CD59|MIC11|MIN1|MIN2|MIN3|MSK21
Gene ID
966
UniProt
P13987
Host
Rabbit
Reactivity
Human
Immunogen
CD59 molecule, complement regulatory protein
Target
CD59
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, FC, IF
Field of Research
Stem Cells, Immunology, Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
18-20 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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