Cleaved CASP9 antibody
Product Specifications
Background
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants.This antibody can recognize the pre- and cleaved- caspase 9.
Synonyms
Caspase-9 (CASP-9) |Apoptotic protease Mch-6|Apoptotic protease-activating factor 3 (APAF-3) |ICE-like apoptotic protease 6 (ICE-LAP6) |Caspase-9 subunit p35|Caspase-9 subunit p10|CASP9|MCH6
Gene ID
842
UniProt
P55211
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Caspase 9, apoptosis-related cysteine peptidase
Target
Cleaved CASP9
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:200 - 1:200; IHC: 1:50 - 1:200; IF: 1:50 - 1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
17 kDa/36 kDa/46 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF
Immunogen Sequence
1-159aa
Curated Selection
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