CASP9 antibody
Product Specifications
Background
Caspase 9, apoptosis-related cysteine protease (CASP9, synonyms: MCH6, APAF3, APAF-3, ICE-LAP6, CASPASE-9c) is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. Caspase 9 is processed by APAF1; this step is thought to be one of the earliest in the caspase activation cascade. FNab01295 can recognize the pre-and cleaved-caspase 9.
Synonyms
Caspase-9 (CASP-9) |Apoptotic protease Mch-6|Apoptotic protease-activating factor 3 (APAF-3) |ICE-like apoptotic protease 6 (ICE-LAP6) |Caspase-9 subunit p35|Caspase-9 subunit p10|CASP9|MCH6
Gene ID
842
UniProt
P55211
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Caspase 9, apoptosis-related cysteine peptidase
Target
CASP9
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IF, IHC, IP, WB, FC
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:1000; IP: 1:200-1:1000; IHC: 1:50-1:200; IF: 1:10-1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
46 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IF, IHC, IP, WB, FC
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