CASP8 antibody
Product Specifications
Background
Caspase 8, also named as MCH5, MACH, FLICE, and CAP4, belongs to the peptidase C14A family. It may participate in the GZMB apoptotic pathways and functions as an upstream regulator in a-bisabolol-induced apoptosis. Caspase 8 catalyzes an essential intermediate step in the ubiquitination and proteasome-mediated degradation of IRF3 (PMID:21816816) . It may control diabetic embryopathy-associated apoptosis via Caspase 8 is expressed as nine isoforms by alternative splicing with the molecular mass from 26 kDa to 62 kDa. This antibody can recognize pro-and cleaved-caspase 8.
Synonyms
Caspase-8 (CASP-8) |Apoptotic cysteine protease|Apoptotic protease Mch-5|CAP4|FADD-homologous ICE/ced-3-like protease|FADD-like ICE (FLICE) |ICE-like apoptotic protease 5|MORT1-associated ced-3 homolog (MACH) |Caspase-8 subunit p18|Caspase-8 subunit p10|CASP8|MCH5
Gene ID
841
UniProt
Q14790
Host
Mouse
Reactivity
Human
Immunogen
Caspase 8, apoptosis-related cysteine peptidase
Target
CASP8
Clonality
Monoclonal
Isotype
IgG1
Applications
ELISA, IHC, WB,IF,IP
Field of Research
Metabolism
Purification
Protein A+G purification
Dilution
WB: 1:500-1:5000; IP: 1:200-1:2000; IHC: 1:100-1:400; IF: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
50-55 kDa, 25-32 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
2C2
Tested Applications
ELISA, IHC, WB, IF, IP
Immunogen Sequence
1-270aa
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