CASP3 antibody
Product Specifications
Background
Caspase 3, also named as CPP32, SCA-1 and Apopain, belongs to the peptidase C14A family. Caspase 3 is involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly (ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Caspase 3 cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and-9. Caspase 3 is involved in the cleavage of huntingtin. The antibody can recognize p17 and p32 of Caspase 3.
Synonyms
Caspase-3 (CASP-3) |Apopain|Cysteine protease CPP32 (CPP-32) |Protein Yama|SREBP cleavage activity 1 (SCA-1) |Caspase-3 subunit p17|Caspase-3 subunit p12|CASP3|CPP32
UniProt
P42574
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Caspase 3, apoptosis-related cysteine peptidase
Target
CASP3
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC, WB,IF,IP
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:2000; IP: 1:200-1:2000; IHC: 1:50-1:500; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
32-35 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC, WB, IF, IP
Immunogen Sequence
Peptide
Curated Selection
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