CACNA1S antibody
Product Specifications
Background
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA) . They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA) . Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle.
Synonyms
Voltage-dependent L-type calcium channel subunit alpha-1S|Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle|Voltage-gated calcium channel subunit alpha Cav1.1|CACNA1S|CACH1|CACN1|CACNL1A3
Gene ID
779
UniProt
Q13698
Host
Rabbit
Reactivity
Human
Immunogen
Calcium channel, voltage-dependent, L type, alpha 1S subunit
Target
CACNA1S
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Neuroscience
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
200-220 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC
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