BUB3 antibody
Product Specifications
Background
Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1.
Synonyms
Mitotic checkpoint protein BUB3|BUB3
Gene ID
9184
UniProt
O43684
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Budding uninhibited by benzimidazoles 3 homolog (yeast)
Target
BUB3
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IF
Field of Research
Cell Division and Proliferation
Purification
Immunogen affinity purified
Dilution
IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IF
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