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BMI1 antibody

Product Specifications

Background

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.

Synonyms

Polycomb complex protein BMI-1|Polycomb group RING finger protein 4|RING finger protein 51|BMI1|PCGF4|RNF51

Gene ID

648

UniProt

P35226

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

BMI1 polycomb ring finger oncogene

Target

BMI1

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, WB, IHC, IF, IP

Field of Research

Epigenetics, Metabolism, Cancer, Developmental biology, Stem Cells, Cell Division and Proliferation

Purification

Immunogen affinity purified

Dilution

WB: 1:500-1:2000; IP: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:10-1:100

Purity

≥95% as determined by SDS-PAGE

Form

Liquid

Molecular Weight

43-45 kDa

Shipping Conditions

4°C with ice bag

Storage Conditions

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Tested Applications

ELISA, WB, IHC, IF, IP

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