CTNNB1 antibody
Product Specifications
Background
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants.
Synonyms
Catenin beta-1|Beta-catenin|CTNNB1|CTNNB
Gene ID
1499
UniProt
P35222
Host
Rabbit
Reactivity
Human, Mouse, Rat, Pig
Immunogen
catenin(cadherin-associated protein), beta 1, 88kDa
Target
CTNNB1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IF, WB, IHC, IP
Field of Research
Epigenetics, Signal Transduction, Metabolism, Immunology, Cancer, Neuroscience, Stem Cells
Purification
Immunogen affinity purified
Dilution
WB: 1:1000-1:4000; IP: 1:500-1:1000; IHC: 1:100-1:400; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
90 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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