BCL2 antibody
Product Specifications
Background
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) . May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785) .
Synonyms
Apoptosis regulator Bcl-2|BCL2
Gene ID
596
UniProt
P10415
Host
Mouse
Reactivity
Human
Immunogen
B-cell CLL/lymphoma 2
Target
BCL2
Clonality
Monoclonal
Isotype
IgG2a
Applications
ELISA, WB, IP, IHC
Field of Research
Neuroscience, Cancer, Immunology, Cardiovascular
Purification
Protein A+G purification
Dilution
WB: 1:1000-1:10000; IP: 1:500-1:5000; IHC: 1:100-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
26 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
8A10
Tested Applications
ELISA, WB, IP, IHC
Immunogen Sequence
1-239aa
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