BBS2 antibody
Product Specifications
Background
The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8 (GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization.
Synonyms
Bardet-Biedl syndrome 2 protein|BBS2
Gene ID
583
UniProt
Q9BXC9
Host
Mouse
Reactivity
Human, Dog
Immunogen
Bardet-Biedl syndrome 2
Target
BBS2
Clonality
Monoclonal
Isotype
IgG2a
Applications
ELISA, WB, IF
Field of Research
Neuroscience, Metabolism
Purification
Protein A+G purification
Dilution
WB: 1:500-1:2000; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
80 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
9F10
Tested Applications
ELISA, WB, IF
Immunogen Sequence
1-325aa
Curated Selection
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