BAIAP2 antibody

The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2, BAI1-associated protein 2, Protein BAP2)|Fas ligand-associated factor 3 (FLAF3)|Insulin receptor substrate p53/p58 (IRS-58, IRSp53/58)|Insulin receptor substrate protein of 53 kDa (IRSp53, Insulin receptor substrate p53)|BAIAP2