BACE1 antibody
Product Specifications
Background
Responsible for the proteolytic processing of the amyloid precursor protein (APP) . Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
Synonyms
Beta-secretase 1|Aspartyl protease 2 (ASP2, Asp 2) |Beta-site amyloid precursor protein cleaving enzyme 1 (Beta-site APP cleaving enzyme 1) |Memapsin-2|Membrane-associated aspartic protease 2|BACE1|BACE|KIAA1149
Gene ID
23621
UniProt
P56817
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Beta-site APP-cleaving enzyme 1
Target
BACE1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IP, IHC
Field of Research
Neuroscience, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:1000; IP: 1:500-1:1000; IHC: 1:100-1:400
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
70-75 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IP, IHC
Immunogen Sequence
150-457aa
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