ATF6B antibody
Product Specifications
Background
The endoplasmic reticulum (ER) -transmembrane proteins, ATF6 alpha (ATF6) and ATF6 beta (ATF6B), are cleaved during the ER stress response (ERSR) . The resulting N-terminal fragments of both ATF6 isoforms, which have conserved basic leucine-zipper and DNA binding domains but divergent transcriptional activation domains, translocate to the nucleus where they bind to ER stress-response elements (ERSE) in ERSR, such as Bip/GRP78. This antibody could recognize ATF6 beta (110kd) and its cleaved forms (60,80kd) (PMID: 11256944)
Synonyms
Cyclic AMP-dependent transcription factor ATF-6 beta (cAMP-dependent transcription factor ATF-6 beta) |Activating transcription factor 6 beta (ATF6-beta) |Protein G13|cAMP response element-binding protein-related protein (Creb-rp) |cAMP-responsive element-binding protein-like 1|Processed cyclic AMP-dependent transcription factor ATF-6 beta|ATF6B|CREBL1|G13
Gene ID
1388
UniProt
Q99941
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Activating transcription factor 6 beta
Target
ATF6B
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF, IP
Field of Research
Signal Transduction, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:1000-1:4000; IP:1:500-1:2000; IHC: 1:20-1:200; IF: 1:10-1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
110 kDa, 60 kDa, 80 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF, IP
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