ARHGEF18 antibody
Product Specifications
Background
Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species (ROS) . Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950) .
Synonyms
Rho guanine nucleotide exchange factor 18|114 kDa Rho-specific guanine nucleotide exchange factor (p114-Rho-GEF, p114RhoGEF) |Septin-associated RhoGEF (SA-RhoGEF) |ARHGEF18|KIAA0521
Gene ID
23370
UniProt
Q6ZSZ5
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Rho/rac guanine nucleotide exchange factor (GEF) 18
Target
ARHGEF18
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Signal Transduction, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
120-130 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC
Curated Selection
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