ARHGEF1 antibody

Product Specifications

Background

Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.

Synonyms

Rho guanine nucleotide exchange factor 1|115 kDa guanine nucleotide exchange factor (p115-RhoGEF, p115RhoGEF) |Sub1.5|ARHGEF1

Gene ID

9138

UniProt

Q92888

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Rho guanine nucleotide exchange factor (GEF) 1

Target

ARHGEF1

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, IHC, WB, IP

Field of Research

Signal Transduction, Metabolism

Purification

Immunogen affinity purified

Dilution

WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200

Purity

≥95% as determined by SDS-PAGE

Form

Liquid

Molecular Weight

102-110 kDa

Shipping Conditions

4°C with ice bag

Storage Conditions

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Tested Applications

ELISA, IHC, WB, IP

Immunogen Sequence

27-84aa

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