APP antibody

Beta-amyloid peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. In vitro, can reduce Cu(2+) and Fe(3+) to Cu(+) and Fe(2+), respectively. Beta-amyloid 42 is a more effective reductant than beta-amyloid 40. Beta-amyloid peptides bind to lipoproteins and apolipoproteins E and J in the CSF and to HDL particles in plasma, inhibiting metal-catalyzed oxidation of lipoproteins. Beta-APP42 may activate mononuclear phagocytes in the brain and elicit inflammatory responses. Promotes both tau aggregation and TPK II-mediated phosphorylation. Interaction with overexpressed HADH2 leads to oxidative stress and neurotoxicity. Also binds GPC1 in lipid rafts. The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.

Amyloid-beta precursor protein (APP)|ABPP|APPI|Alzheimer disease amyloid A4 protein homolog|Alzheimer disease amyloid protein|Amyloid precursor protein|Amyloid-beta (A4) precursor protein|Amyloid-beta A4 protein|Cerebral vascular amyloid peptide (CVAP)|PreA4|Protease nexin-II (PN-II)|N-APP|Soluble APP-alpha (S-APP-alpha)|Soluble APP-beta (S-APP-beta)|C99 Alternative names: Beta-secretase C-terminal fragment (Beta-CTF)|Amyloid-beta protein 42 (Abeta42) Alternative names: Beta-APP42|Amyloid-beta protein 40 (Abeta40) Alternative names: Beta-APP40|C83 Alternative names: Alpha-secretase C-terminal fragment (Alpha-CTF)|P3(42)|P3(40)|C80|Gamma-secretase C-terminal fragment 59 Alternative names: Amyloid intracellular domain 59 (AICD-59, AID(59))|Gamma-CTF(59)|Gamma-secretase C-terminal fragment 57 Alternative names: Amyloid intracellular domain 57 (AICD-57, AID(57))|Gamma-CTF(57)|Gamma-secretase C-terminal fragment 50 Alternative names: Amyloid intracellular domain 50 (AICD-50, AID(50))|Gamma-CTF(50)|C31|APP|A4|AD1