PRKAA2 antibody
Product Specifications
Background
PRKAA2 (protein kinase, AMP-activated, alpha 2 catalytic subunit), also named as AMPKA2, AMPK, PRKAA, AMPK2, belonogs to the CAMK Ser/Thr protein kinase family and SNF1 subfamily. PRKAA2 is an αβγ heterotrimer that is activated by low cellular energy status, such as decreases in both the ATP/AMP ratio and the phosphocreatine content and it is a glycogen synthase kinase, phosphorylating Ser7 at the NH2 terminus, which decreases glycogen synthase activity (PMID:14532170) . The protein can be ubiquitinated (PMID:21224036) .
Synonyms
5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK subunit alpha-2) |Acetyl-CoA carboxylase kinase (ACACA kinase) |Hydroxymethylglutaryl-CoA reductase kinase (HMGCR kinase) |PRKAA2|AMPK|AMPK2
Gene ID
5563
UniProt
P54646
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Protein kinase, AMP-activated, alpha 2 catalytic subunit
Target
PRKAA2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IF, IHC, IP
Field of Research
Cardiovascular, Metabolism, Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:1000-1:10000; IHC: 1:20-1:200; IF: 1:10-1:100; IP:1:500-1:5000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
62 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IF, IHC, IP
Immunogen Sequence
340-552aa
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