AREG antibody
Product Specifications
Background
Amphiregulin (AREG) is one of the ligands of the epidermal growth factor receptor (EGFR) . AREG plays a central role in mammary gland development and branching morphogenesis in organs and is expressed both in physiological and in cancerous tissues. The AREG protein is synthesized as a 252-amino acid transmembrane precursor, pro-AREG. At the plasma membrane, pro-AREG is subjected to sequential proteolytic cleavages within its ectodomain and is then released as the soluble AREG protein. Depending on the cell type and microenvironment, AREG can be produced in multiple cellular and mature forms using alternative pro-AREG cleavage sites and glycosylation motifs. Post-translastional modfications of 50-kDa pro-AREG produces a major soluble 43-kDa form, 28-, 26-, 16-kDa membrane anchored forms, and soluble 21-, 19-, and 9-kDa forms (PMID: 9642297) .
Synonyms
Amphiregulin (AR) |Colorectum cell-derived growth factor (CRDGF) |AREG|AREGB|SDGF
Gene ID
374
UniProt
P15514
Host
Rabbit
Reactivity
Human
Immunogen
Amphiregulin
Target
AREG
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IF, WB, IHC,IP
Field of Research
Immunology, Cardiovascular, Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:2000; IHC: 1:50-1:500; IP: 1:1000-1:10000; IF: 1:10-1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
43 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IF, WB, IHC, IP
Immunogen Sequence
20-252aa
Curated Selection
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