AMFR antibody
Product Specifications
Background
E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation(ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor.
Synonyms
E3 ubiquitin-protein ligase AMFR|Autocrine motility factor receptor (AMF receptor)|RING finger protein 45|gp78|AMFR|RNF45
Gene ID
267
UniProt
Q9UKV5
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
autocrine motility factor receptor
Target
AMFR
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF, IP
Field of Research
Epigenetics, Signal Transduction, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:5000; IF: 1:10-1:100; IHC: 1:20-1:200; IP: 1:200-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
73 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS1233468-01 0.02 mg (E-Coli)
Recombinant Aspergillus niger Probable pectate lyase A (plyA)
Ask
View Details MBS1233468-02 0.02 mg (Yeast)
Recombinant Aspergillus niger Probable pectate lyase A (plyA)
Ask
View Details