AMACR antibody
Product Specifications
Background
AMACR (Alpha-methylacyl-CoA racemase) belongs to the CaiB/BaiF CoA-transferase family. It is a mitochondrial and peroxisomal enzyme that catalyzes the conversion of 2R stereoisomers of phytanic and pristanic acid to their S counterparts. AMACR has previously been shown to be a highly sensitive marker for colorectal and clinically localized prostate cancer (PCa) . However, AMACR expression is down-regulated at the transcript and protein level in hormone-refractory metastatic PCa, suggesting a hormone-dependent expression of AMACR (PMID:12213712) . It has 3 isoforms produced by alternative splicing ang it can form a a dimer of 70-75 kDa (PMID:21812041) . Defects in AMACR are the cause of alpha-methylacyl-CoA racemase deficiency (AMACRD) and congenital bile acid synthesis defect type 4 (CBAS4) .
Synonyms
Alpha-methylacyl-CoA racemase|2-methylacyl-CoA racemase|AMACR
UniProt
Q9UHK6
Host
Rabbit
Reactivity
Human, rat
Immunogen
Alpha-methylacyl-CoA racemase
Target
AMACR
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC, WB
Field of Research
Stem Cells, Immunology, Metabolism, Cancer
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:5000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
42 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC, WB
Immunogen Sequence
171-382aa
Curated Selection
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