ALPL antibody
Product Specifications
Background
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific) . The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. ALPL (Alkaline phosphatase, tissue-nonspecific isozyme) is also named as AP-TNAP, TNSALP and belongs to the alkaline phosphatase family. It can exsit as a homodimer with the molecular weight of 140 kDa (PMID:18724009) . ALPL was synthesized as a 66-kDa endo-b-N-acetylglucos-aminidase H (Endo H) -sensitive form, and processed to an 80-kDa mature form, which is anchored to the plasma membrane via glycosylphosphatidylinositol (GPI) (PMID:10839996) .This antibody can bind the four mentioned alkaline phosphatases.
Synonyms
Alkaline phosphatase, tissue-nonspecific isozyme (AP-TNAP, TNS-ALP, TNSALP) |Alkaline phosphatase liver/bone/kidney isozyme|Phosphoamidase|Phosphocreatine phosphatase|ALPL
Gene ID
249
UniProt
P05186
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Alkaline phosphatase, liver/bone/kidney
Target
ALPL
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, FC
Field of Research
Stem Cells, Cell Division and Proliferation, Metabolism, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:3000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
60-80 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, FC
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