A2M antibody
Product Specifications
Background
Alpha-2-macroglobulin, also known as α2-macroglobulin (α2M or A2M), is a protein abundant in the plasma of vertebrates and several invertebrates. A2M is an evolutionarily conserved arm of the innate immune system. It also mediates the proliferation of T cells and macrophages. A2M acts as a nonspecific protease inhibitor involved in the host defense mechanism that inactivates both endogenous and exogenous proteases, including trypsin, thrombin and collagenase. Even though A2M is produced predominantly by the liver, it may also be expressed in the reproductive tract, heart, and brain, and may have important roles in many physiological processes and medical illnesses including Alzheimer’s disease.
Synonyms
Alpha-2-macroglobulin (Alpha-2-M) |C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5|A2M|CPAMD5
Gene ID
2
UniProt
P01023
Host
Mouse
Reactivity
Human
Immunogen
Alpha-2-macroglobulin
Target
A2M
Clonality
Monoclonal
Isotype
IgG2a
Applications
ELISA, IHC, WB
Field of Research
Immunology, Cardiovascular, Metabolism, Signal Transduction
Purification
Protein A+G purification
Dilution
WB: 1:500-1:2000; IP: 1:500-1:1000; IF: 1:50-1:500; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
185 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
6D0
Tested Applications
ELISA, IHC, WB
Immunogen Sequence
1100-1474aa
Curated Selection
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