SERPINA3 antibody
Product Specifications
Background
Human SerpinA3, also known as Alpha 1-antichymotrypsin (AACT), is a member of the serine protease inhibitor class, and is a plasma alpha globulin glycoprotein which increases in the blood during the inflammatory process. SerpinA3, is also an inhibitor of neutrophil cathepsin G, mast cell chymases and pancreatic chymotrypsin. SerpinA3 is produced primarily in the liver, and is identified as an acute-phase inflammatory protein. SerpinA3 deficiency has been associated with liver disease. SerpinA3 has also been implicated in the pathology of a number of devastating human diseases including chronic obstructive pulmonary disease (COPD), Parkinson’s disease (PD), Alzheimer’s disease (AD), Stroke, Cystic Fibrosis, Cerebral Haemorrhage and Multiple System Atrophy.
Synonyms
Alpha-1-antichymotrypsin (ACT) |Cell growth-inhibiting gene 24/25 protein|Serpin A3|Alpha-1-antichymotrypsin His-Pro-less|SERPINA3|AACT
Gene ID
12
UniProt
P01011
Host
Mouse
Reactivity
Human
Immunogen
Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
Target
SERPINA3
Clonality
Monoclonal
Isotype
IgG2b
Applications
ELISA, WB, IHC
Field of Research
Cancer, Immunology, Cardiovascular, Metabolism
Purification
Protein A+G purification
Dilution
WB: 1:1000-1:10000; IHC: 1:20-1:300
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
60 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
8F10
Tested Applications
ELISA, WB, IHC
Immunogen Sequence
104-326aa
Curated Selection
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