AKAP8L antibody

Could play a role in constitutive transport element (CTE) -mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export (PubMed:10748171, PubMed:11402034) . Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA (PubMed:10761695, PubMed:11884601) . May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis (PubMed:11034899) . May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta (PubMed:12538639) . Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function seems to act redundantly with AKAP8 (PubMed:16980585) . May be involved in regulation of pre-mRNA splicing (PubMed:17594903) . (Microbial infection) In case of EBV infection, may target PRKACA to EBNA-LP-containing nuclear sites to modulate transcription from specific promoters (PubMed:11884601) . Can synergize with DHX9 to activate the CTE-mediated gene expression of type D retroviruses (PubMed:11402034) . In case of HIV-1 infection, involved in the DHX9-promoted annealing of host tRNA (Lys3) to viral genomic RNA as a primer in reverse transcription; in vitro negatively regulates DHX9 annealing activity (PubMed:25034436) .

A-kinase anchor protein 8-like (AKAP8-like protein) |Helicase A-binding protein 95 (HAP95) |Homologous to AKAP95 protein (HA95) |Neighbor of A-kinase-anchoring protein 95 (Neighbor of AKAP95) |AKAP8L|NAKAP|NAKAP95