ADSL antibody
Product Specifications
Background
ADSL(adenylosuccinate lyase) is also named as AMPS, ASase, ASL and belongs to the lyase 1 family. It is an enzyme involved in 2 pathways of purine nucleotide metabolism and catalyzes cleavage of succinyl groups to yield fumarate(PMID:18524658). Defects in ADSL are the cause of adenylosuccinase deficiency(ADSL deficiency). In humans, mutations in ADSL lead to an inborn error of metabolism originally characterized by developmental delay, often with autistic features(PMID:20884265)..The ADSL enzymatic activity is reduced in lymphocytes and red blood cells of the patient with severe psychomotor retardation(PMID:9545543). It has 2 isoforms produced by alternative splicing.
Synonyms
Adenylosuccinate lyase (ADSL, ASL)|Adenylosuccinase (ASase)|ADSL|AMPS
Gene ID
158
UniProt
P30566
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
adenylosuccinate lyase
Target
ADSL
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF, FC
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:5000; IHC: 1:20-1:200; IF: 1:10-1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
55 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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