ADAR antibody
Product Specifications
Background
ADAR1 is also named as ADAR1, DSRAD, G1P1, IFI4. It convert selected adenosine residues into inosine in substrate RNAs containing a relatively short dsRNA region (PMID:15556947) . The human ADAR1 gene specifies two size forms of RNA-specific adenosine deaminase, an interferon (IFN) inducible ?150 kDa protein and a constitutively expressed N-terminally truncated ?110 kDa protein, encoded by transcripts with alternative exon 1 structures that initiate from different promoters (PMID:11111054) . It has 5 isoforms produced by alternative promoter usage and alternative splicing. Defects in ADAR are a cause of dyschromatosis symmetrical hereditaria (DSH) .ADAR1 can form respective homodimers, and this association is essential for its enzymatic activities (PMID:17428802) .
Synonyms
Double-stranded RNA-specific adenosine deaminase (DRADA) |136 kDa double-stranded RNA-binding protein (p136) |Interferon-inducible protein 4 (IFI-4) |K88DSRBP|ADAR|ADAR1|DSRAD|G1P1|IFI4
Gene ID
103
UniProt
P55265
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Adenosine deaminase, RNA-specific
Target
ADAR
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC, IF, WB, IP
Field of Research
Neuroscience, Immunology, Metabolism, Epigenetics
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:50-1:200; IP: 1:200-1:1000; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
110 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC, IF, WB, IP
Immunogen Sequence
Peptide
Curated Selection
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