ACTN4 antibody
Product Specifications
Background
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable) . Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161) . Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity) . May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778) .
Synonyms
Alpha-actinin-4|Non-muscle alpha-actinin 4|ACTN4
Gene ID
81
UniProt
O43707
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Actinin, alpha 4
Target
ACTN4
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF, IP, FC
Field of Research
Immunology, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:5000; IHC: 1:20-1:200; IP: 1:500-1:5000; IF: 1:10-1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
105 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF, IP, FC
Immunogen Sequence
720-911aa
Curated Selection
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