ACOX1 antibody
Product Specifications
Background
The protein encoded by this gene is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Alternatively spliced transcript variants encoding different isoforms have been identified.It has 3 isoforms produced by alternative splicing with the molecular mass of 70-74 kDa and can be cleaved post-translationally into a 50-kDa and a 22-kDa subunit between Val468 and Ala469 (PMID: 10672038) .
Synonyms
Peroxisomal acyl-coenzyme A oxidase 1 (AOX) |Palmitoyl-CoA oxidase|Peroxisomal fatty acyl-CoA oxidase|Straight-chain acyl-CoA oxidase (SCOX) |Peroxisomal acyl-CoA oxidase 1, A chain|Peroxisomal acyl-CoA oxidase 1, B chain|Peroxisomal acyl-CoA oxidase 1, C chain|ACOX1|ACOX
Gene ID
51
UniProt
Q15067
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Acyl-Coenzyme A oxidase 1, palmitoyl
Target
ACOX1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF
Field of Research
Metabolism, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:100 - 1:200; IF: 1:50 - 1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
74 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF
Immunogen Sequence
1-270aa
Curated Selection
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