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Fomepizole (Standard)

Fomepizole (Standard) is the analytical standard of Fomepizole. This product is intended for research and analytical applications. Fomepizole (4-Methylpyrazole) is a potent cytochrome P450 (CYP2E1) inhibitor. Fomepizole is a competitive inhibitor of the enzyme alcohol dehydrogenase. Fomepizole blocks further conversion of methanol and ethylene glycol to toxic metabolites. Fomepizole has the potential for an antidote for ethylene glycol or methanol poisoning[1][2][3].

Product Specifications

CAS Number

7554-65-6

Product Name Alternative

4-Methylpyrazole (Standard)

UNSPSC

12352005

Target

Cytochrome P450; Reference Standards

Type

Reference Standards

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/fomepizole-standard.html

Smiles

CC1=CNN=C1

Molecular Formula

C4H6N2

Molecular Weight

82.10

References & Citations

[1]Casavant MJ. Fomepizole in the treatment of poisoning. Pediatrics. 2001 Jan;107 (1) :170.|[2]Lepik KJ, et al. Adverse drug events associated with the antidotes for methanol and ethylene glycol poisoning: a comparison of ethanol and fomepizole. Ann Emerg Med. 2009 Apr;53 (4) :439-450.e10.|[3]Garrett Rampon, et al. Use of fomepizole as an adjunct in the treatment of acetaminophen overdose: a case series. Toxicology Communications. Volume 4, 2020 - Issue 1.|[4]Páez AM, et al. Effects of 4-methylpyrazole on ethanol neurobehavioral toxicity in CD-1 mice. Acad Emerg Med. 2004 Aug;11 (8) :820-6.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

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