12-epi-LTB4
Product Specifications
UNSPSC Description
12-epi-LTB4 is an agonist for BLT1 and BLT2. 12-epi LTB4 exhibits a partial agonistic activity against mBLT1 and mBLT2, and induces phosphorylation of extracellular signal-regulated kinase in primary mouse keratinocytes[1][2].
Target Antigen
Leukotriene Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/12-epi-ltb4.html
Smiles
O[C@@H](CCCC(O)=O)/C=C\C=C\C=C\[C@@H](O)C/C=C\CCCCC
Molecular Weight
336.47
References & Citations
[1]Yokomizo T, et al. Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2. J Biol Chem. 2001 Apr 13;276(15):12454-9.|[2]Iizuka Y, et al. Characterization of a mouse second leukotriene B4 receptor, mBLT2: BLT2-dependent ERK activation and cell migration of primary mouse keratinocytes. J Biol Chem. 2005 Jul 1;280(26):24816-23.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-137350/12-epi-LTB4-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-137350/
CAS Number
83709-73-3
Available Sizes
Curated Selection
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