12-epi-LTB4

12-epi-LTB4 is an agonist for BLT1 and BLT2. 12-epi LTB4 exhibits a partial agonistic activity against mBLT1 and mBLT2, and induces phosphorylation of extracellular signal-regulated kinase in primary mouse keratinocytes[1][2].

Product Specifications

CAS Number

[83709-73-3]

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

Leukotriene Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/12-epi-ltb4.html

Solubility

10 mM in DMSO

Smiles

O[C@@H](CCCC(O)=O)/C=C\C=C\C=C\[C@@H](O)C/C=C\CCCCC

Molecular Formula

C20H32O4

Molecular Weight

336.47

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Yokomizo T, et al. Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2. J Biol Chem. 2001 Apr 13;276 (15) :12454-9.|[2]Iizuka Y, et al. Characterization of a mouse second leukotriene B4 receptor, mBLT2: BLT2-dependent ERK activation and cell migration of primary mouse keratinocytes. J Biol Chem. 2005 Jul 1;280 (26) :24816-23.