Dorzolamide-d3 (hydrochloride)
Dorzolamide-d3 hydrochloride is deuterated labeled Dorzolamide hydrochloride. Dorzolamide (L671152) hydrochloride is a potent carbonic anhydrase II inhibitor, with IC50 values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity[1].
Product Specifications
Product Name Alternative
L671152-d3 (hydrochloride) ; MK507-d3 (hydrochloride)
UNSPSC
12352005
Target
Carbonic Anhydrase; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Others
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Others
Solubility
10 mM in DMSO
Smiles
O=S(C(S1)=CC2=C1S([C@@H](C)C([2H])([2H])[C@]2([2H])NCC)(=O)=O)(N)=O.Cl
Molecular Formula
C10H14D3ClN2O4S3
Molecular Weight
363.92
References & Citations
[1]Belal M Ali, et al. Dorzolamide synergizes the antitumor activity of mitomycin C against Ehrlich's carcinoma grown in mice: role of thioredoxin-interacting protein. Naunyn Schmiedebergs Arch Pharmacol. 2015 Dec;388 (12) :1271-82.|[2]J Biollaz, et al. Whole-blood pharmacokinetics and metabolic effects of the topical carbonic anhydrase inhibitor dorzolamide. Eur J Clin Pharmacol. 1995;47 (5) :455-60.|[3]Sangly P Srinivas, et al. Inhibition of carbonic anhydrase activity in cultured bovine corneal endothelial cells by dorzolamide. Invest Ophthalmol Vis Sci. 2002 Oct;43 (10) :3273-8.|[4]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
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